Signorelli developed the health system’s first national laboratory service line and launched a laboratory utilization program that saved the system $50 million. During the COVID-19 pandemic, she created HCA’s testing algorithm and helped source testing methods with 48-hour turnarounds. She also subsequently reduced testing turnarounds to 24 hours. Signorelli previously served as chief laboratory officer for HCA’s Continental Division, and as a pathologist at testing firm Unipath.