Isaacs runs the largest medical group in the nation—nearly 11,000 physicians and more than 40,000 staff in Northern California, Maryland, Virginia and Washington, D.C. He has advanced creative care-delivery models, including a joint replacement program that garnered a 2019 innovation award from the National Committee on Quality Assurance. In 34 months, the percentage of patients in that program recovering at home climbed to 82%, up from 12%. He is also pushing greater use of predictive analytics across the medical group.