Clark, 51, first joined Mayo in 1997 as a unit manager in accounting, rising through the ranks and leading to a number of research administration roles with increasing responsibilities. He now oversees a $675 million operating budget supporting 1,500 physicians and 3,250 staff members.

Sponsored Content from the Furst Group

"I worry about people who don't make mistakes because that means they're not stretching enough to make a difference."

Read the complete Furst Group interview with Leon Clark.