Lakeland (Fla.) Regional Health and Orlando (Fla.) Health lasted less than a year as integrated partners, and will break up on Sept. 30.
The two initially affiliated on Oct. 1, 2017, as a means to improve access to care and enhance quality.
"We have concluded that because of our different strategies and distinctive communities served, these goals can best be achieved independently," Lakeland CEO Elaine Thompson said.
Orlando Health officials in an emailed statement said that after serious deliberation, the system "has decided to release Lakeland Regional Health from our health system in exchange for significant financial and strategic consideration. Orlando Health looks forward to expanding our interests and developing new opportunities in Polk County."
Lakeland's Thompson maintained that hospital is still financially strong, as it was before entering the affiliation.
Lakeland's financial statement for the first nine months of the current fiscal year, which ends Sept. 30, showed total net income of $17.3 million on net patient revenue of $590 million. That is down from a year earlier when Lakeland reported total net income of $45.8 million on net patient revenue of $567.4 million.
Orlando Health, meanwhile, recorded net income of $318.6 million on net patient revenue of $3.04 billion, in the same nine-month period ended June 30. A year earlier, Orlando Health reported net income of $259.5 million on net patient revenue of nearly $2 billion.
Lakeland's news release said it will continue to collaborate with the Mayo Clinic Care Network and Nemours Children's Health System.