Lilliam Barrios-Paoli, chair of NYC Health & Hospitals board of directors, will resign Oct. 7.
Barrios-Paoli served just one year at New York City's largest public health system.
Vice Chair Gordon Campbell will act as interim chair until a permanent replacement is selected, according to a spokesman.
In a prepared statement, Barrios-Paoli said, "It has been an honor to serve as board chair of Health & Hospitals for this past year. Although I have decided to step down as chair of the board, I remain committed to the mission of this essential public health care system."
Barrios-Paoli will leave her other roles at NYC Health & Hospitals, including chair of the IT committee and health services administrator.
Barrios-Paoli was previously deputy mayor of health and human services for New York Mayor Bill de Blasio from 2014 to 2015. She left for the chair position at the NYC Health & Hospitals amid criticism of the city's handling of homelessness, Politico reported.
She was previously commissioner of the New York City Department for the Aging under former New York Mayor Michael Bloomberg.
A force in the not-for-profit sector, Barrios-Paoli was president and CEO of Safe Space NYC, an organization that serves more than 25,000 children and families, and senior VP and chief executive for agency services at the United Way of New York City, which focuses on helping low-income people get access to services.
NYC Health & Hospitals is an 11-hospital system with a budget of $7.2 billion and serves 1.4 million people in New York. The system is in the midst of efforts to financially turna round. It faces a potential budget gap of $1.8 billion by fiscal 2020.