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October 10, 2015 01:00 AM

Using software to avoid misdiagnoses

Sabriya Rice
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    In 2012, a preteen entered the emergency department at Children's National Medical Center in Washington, D.C., with a high fever, weight loss and diarrhea. The attending pediatrician suspected a rare, travel-related infectious disease, as the child had just been in Southeast Asia.

    Specialists combed through the Centers for Disease Control and Prevention website for health alerts from the region. They ran tests. All came back negative.

    Only after two days did the hospital turn to a diagnostic decision-support software program called Isabel. Once a clinician typed in the child's symptoms, a list of potential conditions popped up within seconds.

    The specialists quickly realized their initial mistake. “Biased by the patient's travel history, we didn't consider a pretty straightforward diagnosis,” recalled Dr. Paul Manicone, associate chief of the hospitalists division for Children's National Health System. Isabel directed the team's attention to hyperthyroidism, a condition they had overlooked.

    Software programs such as Isabel have been available for decades. “And they have been underutilized for decades,” said Dr. Mark Graber, a member of the National Academy of Medicine's Committee on Diagnostic Error in Healthcare. “That's the real shame.”

    In September, the committee called diagnostic mistakes a persistent blind spot amid efforts to improve quality and safety in healthcare settings. The report recommended research into computer-assisted diagnosis technology.

    Diagnosis-assist programs are particularly helpful in difficult or rare cases. Users enter symptoms, such as fever, abdominal pain and skin rash, and patient characteristics, such as medical history and gender. The software generates a list of diagnoses and ranks them in order of likelihood.

    MH Strategies

    Winning support for diagnostic software use

    Focus initial efforts on clinical areas at highest risk of diagnostic error, especially the ICU and ED.

    Encourage physicians to take a diagnostic pause to ask: “Is there anything else to consider?”

    Start at top of the hierarchy: Residents often feel uncomfortable challenging senior staff.

    Make software readily available through electronic health records, on tablets and on desktops.

    Studies suggest the programs have been successful in boosting physicians' diagnostic confidence, reducing costs and improving patient outcomes. At Children's National, checklists generated by Isabel pointed to the correct diagnosis in 43% of pediatric ailments, according to preliminary findings shared with Modern Healthcare.

    In 2000, DXplain, a similar tool, was offered to general medicine residents at the Mayo Clinic's St. Marys Hospital in Rochester, Minn. Clinicians were encouraged to use it for “diagnostically challenging” cases.

    A subsequent analysis found DXplain helped reduce costs for Medicare Part A patients by an average of $900.

    If used nationwide, the savings for Medicare patients alone could approach $100 million annually, according to a 2010 study in the International Journal of Medical Informatics.

    Despite such findings, “it's been a hard sell,” acknowledged Dr. Edward Hoffer of Massachusetts General Hospital's Computer Science Lab. He's part of the team that launched DXplain in 1985. “The main problem we face is trying to convince overconfident physicians that they actually need to use it.”

    Physician overconfidence is a major stumbling block to wider use. A 2013 study in JAMA Internal Medicine found overconfidence may prevent physicians from re-examining difficult cases in which their diagnosis is more likely to be incorrect. Unwarranted certitude “is the big challenge we face,” Hoffer said.

    Even the Mayo hospital that had success with DXplain no longer uses it. But Hoffer said about 30 U.S. medical schools as well as 15 hospitals, clinics and healthcare systems license the product, which ranges in cost from about $500 a year for a small practice to $12,000 for a large system.

    Diagnosis-assist programs are helpful in managing difficult or rare cases.

    Donald Bauman, CEO of Isabel Healthcare, which launched the tool in 2004, says it is used by about 130 U.S. organizations, including physician practices, medical schools, hospitals and health systems. A subscription for Isabel can range from $299 a year for an individual to as much as $15,000 for a large practice of 75 providers or more.

    Doctors at Children's National initially resisted Isabel, but embraced it after the facility focused on clinical areas with the highest risk of diagnostic mistakes, such as in the intensive-care unit, the emergency department and among hospitalists. “These are areas where patients get large workups and focus is on the diagnostic process,” Manicone said. “That's different from areas like cardiology, where the diagnosis has already been made and the focus is on managing the disease.”

    Physicians argue they don't have time, but using the program takes only a few minutes, and can have a big impact on patient care, said Graber, an enthusiastic proponent of the software. Just because a clinician is 100% sure of a diagnosis “doesn't mean we're right.”

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