The University of South Carolina says shots have been fired at its new School of Public Health in downtown Columbia.
The school issued two alerts on the shooting via its emergency system and Twitter on Thursday. The alerts said people should seek safe shelter and remain indoors.
There was no immediate word on injuries or the number of suspects who might be involved.
A Columbia police spokeswoman referred questions to the school. A school spokesman would not immediately comment.
The shooting happened a couple of blocks from the Statehouse in downtown Columbia.