Deaths and severity of illness related to Clostridium difficile-associated disease, or CDAD, are on the rise in the U.S., according to a new report.
CDAD hospitalizations among adults grew 54% from 2000 to 2005 and the age-adjusted, case-fatality rate for CDAD patients nearly doubled to 2.2% in 2004 from 1.2% in 2000, researchers found in their new report, published in the June issue of Emerging Infectious Diseases. CDAD hospitalizations increased the highest among patients aged 65 to 84, according to the report.
The increase in the severity of C. difficile as it becomes less susceptible to antibiotics likely has led to more CDAD deaths, the researchers concluded. Allocation of public health resources aimed at prevention of CDAD is necessary to mitigate this growing epidemic, they wrote.
The journal is a Centers for Disease Control and Prevention publication. The study relied on discharge data from the National Inpatient Sample, a research database managed by the Agency for Healthcare Research and Quality. The findings echo a similar report released in April by the AHRQ, which showed hospital-acquired infections caused by C. difficile bacteria more than doubled from 2001 to 2005. -- by Jean DerGurahian