's Best Places to Work in Healthcare program recognizes outstanding employers in the healthcare industry on a national level. Below are the Best Places to Work in Healthcare for 2010 - Large Companies.
| LARGE COMPANY RANK | OVERALL RANK | EMPLOYER |
| 1 | 2 | CHRISTUS St. Michael Health System |
| 2 | 4 | Premier |
| 3 | 6 | Southern Ohio Medical Center |
| 4 | 7 | Holy Name Medical Center |
| 5 | 8 | Memorial Healthcare System |
| 6 | 10 | Valley Medical Center |
| 7 | 12 | Pikeville Medical Center |
| 8 | 23 | St. Mary Medical Center |
| 9 | 28 | PAML |
| 10 | 29 | Palmetto Health |
| 11 | 31 | St. Francis Medical Center |
| 12 | 37 | Hays Med |
| 13 | 38 | VHA |
| 14 | 43 | Baptist Health South Florida |
| 15 | 44 | Poudre Valley Health System |
| 16 | 47 | Mercy Gilbert Medical Center |
| 17 | 52 | Roper St. Francis Healthcare |
| 18 | 53 | Union Hospital |
| 19 | 56 | SSM Health Care |
| 20 | 61 | Baptist Hospital |
| 21 | 62 | Goshen Health System |
| 22 | 66 | PinnacleHealth System |
| 23 | 69 | Kootenai Health |
| 24 | 70 | The Advisory Board Co. |
| 25 | 74 | St. Francis Hospital-The Heart Center |
| 26 | 78 | Indiana Regional Medical Center |
| 27 | 83 | Cook Children's Health Care System |
| 28 | 84 | Chandler Regional Medical Center |
| 29 | 86 | Signature HealthCARE |
| 30 | 88 | HCA Virginia Health System-Richmond Market |
| 31 | 89 | Catholic Healthcare West |
| 32 | 90 | AtlantiCare |
| 33 | 92 | Clark Memorial Hospital |
| 34 | 93 | Woman's Hospital |
| 35 | 94 | Centegra Health System |
| 36 | 95 | Firelands Regional Medical Center |
| 37 | 98 | St. Joseph's Hospital and Medical Center |
| 38 | 100 | Rush-Copley Medical Center |
