| 2009 rank | Employer (2008 rank) | Location | Category | Employees | Web site |
| 1 | Intelligent InSites | Fargo, N.D. | Suppliers | 27 | intelligentinsites.com |
| 2 | Doctors Hospital of Sarasota | Sarasota, Fla. | Providers | 472 | doctorsofsarasota.com |
| 3 | CHRISTUS St. Michael Health System (7) | Texarkana, Texas | Providers | 1,929 | christushealth.org |
| 4 | Holy Name Hospital (6) | Teaneck, N.J. | Providers | 1,750 | holyname.org |
| 5 | Sage Products | Cary, Ill. | Suppliers | 563 | sageproducts.com |
| 6 | Memorial Healthcare System | Hollywood, Fla. | Providers | 9,319 | mhs.net |
| 7 | VHA (76) | Irving, Texas | Suppliers | 1,501 | vha.com |
| 8 | Awarepoint Corp. (8) | San Diego | Suppliers | 36 | awarepoint.com |
| 9 | Premier | Charlotte, N.C. | Suppliers | 1,236 | premierinc.com |
| 10 | Valley Medical Center (34) | Renton, Wash. | Providers | 2,184 | valleymed.org |
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| 11 | Texas Health Harris Methodist Hospital Southlake | Southlake | Providers | 115 | texashealthsouthlake.com |
| 12 | King's Daughters Medical Center (5) | Ashland, Ky. | Providers | 3,269 | kdmc.com |
| 13 | Kootenai Health | Coeur d'Alene, Idaho | Providers | 1,812 | kootenaihealth.org |
| 14 | Trilogy Health Services | Louisville, Ky. | Providers | 125 | trilogyhs.com |
| 15 | LiquidAgents Healthcare | Plano, Texas | Suppliers | 40 | liquidagents.com |
| 16 | South Dayton Acute Care Consultants | Dayton, Ohio | Providers | 51 | sdacc.com |
| 17 | Buena Vista Regional Medical Center | Storm Lake, Iowa | Providers | 350 | bvrmc.org |
| 18 | Saint Francis Medical Center (4) | Cape Girardeau, Mo. | Providers | 1,750 | sfmc.net |
| 19 | Indiana Regional Medical Center (2) | Indiana, Pa. | Providers | 1,213 | indianarmc.org |
| 20 | Sutter Maternity and Surgery Center | Santa Cruz, Calif. | Providers | 193 | sutterhealth.org |
